A Student Questions Take Home Exam - 1786 Words

Bio 5309 Graduate Student Questions Take Home Exam 1 Fall 2016 Question There’s a lot of excitement these days about a type of cellular immunotherapy known as CAR-T, a method of modifying peoples’ immune cells to fight cancer. But you could also fill a book listing all the problems its makers will have to solve—how to test, manufacture, and even the define the nature of these cancer-killing cells—before the CAR-T story is a successful one. Is the following statement true or false? Why? â€Å"The cells that are delivered back into the patient are not what ends up doing the bulk of the therapeutic work.† INTRODUCTION The genetic modification and characterization of T-cells with chimeric antigen receptors (CARs) allow functionally distinct T-cell subsets to recognize specific tumor cells. The incorporation of costimulatory molecules or cytokines can enable engineered T-cells to eliminate tumor cells. CARs are designed in a modular fashion and generated by fusing the antigen-binding region of a monoclonal antibody (mAb); extracellular target-binding domain to a transmembrane domain and intracellular-signaling domains. They have shown clinical benefit in patients treated with CD19-directed autologous T-cells. Recent successes suggest that the modification of T-cells with CARs could be a powerful approach for developing safe and effective cancer therapeutics (Dai et al 2016). Chemotherapy and radiation have been used for treatment of cancer since long time but many of theShow MoreRelatedStandardized Testing in Saudi Arabia1435 Words   |  6 Pagespeople can demonstrate justice to include education. Specifically, there are numerous students and teachers who suffer every day from injustice. Some students suffer from the weak education system in their countries while others suffer from mistreatment by their teachers. This alone is an injustice because students attend schools and universities in order to be good people for their countries in the future, and students expect their teachers and administrators to provide a good learning environment forRead MoreCommon Core Is A Hassle Throughout The Nation1717 Words   |  7 Pagesin schools. Common Core implements more rigorous standards, even though students are already having trouble with previous standards. Common Core state standards are an attempt to make American schools compete with the best education s ystems worldwide (Avoid). Implementing the use of more technology, incorporating more critical thinking questions, and having to apply the knowledge to tasks in the tests shows a change students aren’t ready for. The change happened too quickly when Florida signed inRead MoreAre Standardized Exams Sufficient as a Test of Knowledge?1186 Words   |  5 Pageseducation is whether standardized exams are a good way to test the knowledge of a student and whether they should be given in a school to determine if a child advances. Standardized exams are a subject many people feel very strongly about. Some believe that it is stressful and time consuming; others consider that it can be beneficial. I believe that standardized exams should not be given to students and should not be used to determine the knowledge of students or advancement to the next grade levelRead MoreCheating, Its Consequences, And Findings On Cheating1685 Words   |  7 PagesExecutive Summary: The purpose of this paper is to discuss the practice of cheating and its consequences in the graduate students. Lot of papers, scholarly articles have been written around this topic describing the behavior and attitude of the students towards the practice of cheating. There are various factors that can force the students to cheat, irrespective of which the student is expected to submit genuine work of his own to the school. This paper discuss few of the main reasons behind the practiceRead MoreEducation in Vietnam vs America Essay1219 Words   |  5 PagesPhung Nguyen English 112 D18 Professor William December 10, 2014 Education System in Vietnam versus in America â€Å"The United States system of education that has been created for students in Kindergarten through High School is the best educational system in the world. No exceptions. No disclaimers. No doubt. It is simply the best† (Pat Quinn). This means that in many other countries, especially developing countries, the education systems are still old, and Vietnam is one of those countries. AlthoughRead MoreHonors Honor Code And Academic Integrity1084 Words   |  5 Pagesapproximately 5,400 undergraduate students and 2,700 graduate students. Princeton’s Honor Code was created in 1893 and functions to uphold academic integrity at the university. They abide by an Honor Code Constitution that has been revised throughout the years. Students can access their rights in a document entitled Rights, Rules, and Responsibilities. The Honor Code applies to all in class assessments such as tests, quizzes, and in-class papers. Before students take exams, they pledge that they â€Å"willRead MoreInformation Flow, Utilization And Business Value1749 Words   |  7 PagesIT ecosystem and gets the correct links for establishing services, providing training and also staffing for their clients. ABOUT THE PROJECT: This project is based on creating a website for conducting examinations online. Currently conducting exams to employees manually is becoming overhead because of maintaining the material and there is possibility of leaking of paper. Security is also one of the main problem, to maintain security it includes money and man power, there is loss in terms of moneyRead MoreOnline Learning Is Good Or Traditional Learning?847 Words   |  4 Pagesmany things like banking, shopping, and communication using technology in our daily lives. And, the next big thing, which has been growing very fast, is online learning. It is very easy to take online classes via internet. People taking online classes do not go to a college campus, so they do everything from home using technology. Some people think that online learning is not good because it has many drawbacks. For example, online learning involves cheating and lack of class interaction, so they doRead MoreHandout 01BOSTON UNIVERSITYDepartment Of Me chanical EngineeringMechanics1188 Words   |  5 Pagesbarbone@bu.edu. Website: http://learn.bu.edu Text: Sanjay Govindjee, Engineering Mechanics of Deformable Solids, Oxford; 2013. ISBN: 978-0-19-965164-1 Grading: Approximate allocations of credit for work for the semester is as follows: Midterm exam: Final Exam: Design and Project Assignments: Laboratory Reports from Demonstrations (3): Quizzes: Teaching Fellows: Saman Seifi ’Lekan Babaniyi 20% 20% 20% 20% 20% samansei@bu.edu lekanb@bu.edu Important Information: †¢ Failure to turn in any one of theRead MoreAp Psychology1425 Words   |  6 PagesAP Psychology Free Response Questions Sample The following questions are samples of the free response questions from past AP Psychology exams. The free response sections are worth 33 1/3 percent of the total grade. Students have 50 minutes to answer two questions. The key to successfully answering these questions is to: completely define the terms using appropriate psychological terminology and then critically apply each term. Many students concentrate their efforts on the multiple-choice

Haydn And Beethoven Classical And Romantic Composers

Background Both Haydn and Beethoven are known as two of the greatest classical/romantic composers in the history of music. Haydn is identified as the father of modern symphony, as well as the father of the string quartet. He has played an essential role in developing the piano trio and the sonata form. Beethoven is also a widely recognized composer in Western music, his style joined the lull between the Classical and Romantic eras. Beethoven traveled to Vienna when he was young to study under Haydn. However, due to disputes and differences between the two composers, lessons only lasted for a little over a year. The teachings, if only for a short period, left a mark on Beethoven, and can be observed in his compositions. When comparing compositions of the two composers, the two composers differ in several areas, such as form, tonality, theme, and structure. Haydn’s compositions were more relevant with the classical era. His pieces were more constructed on melody and vastly linear. Whereas Beethoven set off to use more of a dynamic contrasting sound in his compositions. First off, comparing a movement in Haydn’s symphony No. 95 in C minor and Beethoven’s symphony No. 5. The first movement of both pieces start off in their own unique way. Haydn’s work begins stridently with a quick timpani strike accompanied by the strings, then is followed by a toned-down melody in C-minor. The second theme of Haydn’s first movement is more jovial sounding and is in C-major. After theShow MoreRelatedLudwig Van Beethoven s Influence On The Classical Era938 Words   |  4 Pagesthe most influential musician of all time, Ludwig van Beethoven was born in Bonn, Germany in 1770. Beethoven’s talent was noticed at a young age and he soon became a pioneer in the world of music for breaking the traditional bounds of style and form. Over the course of his life, Beethoven produced nine symphonies, seven concertos, and a total of forty-two sonatas. Although these numbers are few when compared to other composers such as Joseph Haydn, his work was very substantial. Ludwig van Beethoven’sRead MoreThe Influences of the Classical Period Essay582 Words   |  3 Pages â€Å"There was no one near to confuse me, so I was forced to become original.† This quote is by Joseph Haydn, an Austrian composer who was one of the most prominent during the Classical Period. His signature place in this Period was shared with other great composers like Wolfgang Amadeus Mozart, and Ludwig van Beethoven. The music during the Classical Period significantly changed after the Baroque Period. The techniques and tastes during this Period changed from loudly expressive andRead MoreEssay on The Great Classics of the Classical Period505 Words   |  3 PagesBaroque period, the Classical period is one of the greatest musical eras in history. The style flowed directly off of its Baroque predecessors, smooth, but differing in the tempo. Many of the greatest composers emanated from the Classical era, Haydn, Mozart, and Beethoven among them. This time period transformed the course of not just musical history, but that of the entire modern w estern world. Johann Sebastian Bach was the Alpha and the Omega of the Baroque period. Classical music, as we referRead MoreDevelopment Of Symphonies And Their Composers1346 Words   |  6 PagesDevelopment of Symphonies and Their Composers Early eighteenth century the term â€Å"symphony† was applied to the instrumental preludes and postludes of vocal pieces such as arias and songs. By derivation the word means simply â€Å"a music ensemble†. Today, we apply the term to a much larger composition such as an orchestra (typically in three or four movements). The symphony can also be defined as a sonata for orchestra. Symphonies of the earlier era, the classical era, were mostly simpler, and followedRead MoreThe History And Transitions Of Music933 Words   |  4 Pagestransitions of music has had many talented persons that have influenced music but none are so well known as Franz Joseph Haydn, Wolfgang Amadeus Mozart and Ludwig van Beethoven. All three of these great composers performed during the Classic period and it would act as the base of classic music for the next one hundred and fifty, to two hundred years. The names of Haydn, Mozart and Beethoven are so well known that people who have little to no k nowledge of music will recognize their names. The urban communitiesRead More Beethoven Essay886 Words   |  4 PagesBeethoven Ludwig van Beethoven was, and remains today, an influential figure in the history of classical music. Perhaps no other composer in history wrote music of such inspiring power and expressiveness. His influence on the last 150 years of music is unequalled. Beethoven was born in Bonn, Germany in 1770. His father, a music enthusiast, dreamed of molding his son into the next Mozart. Beethoven never showed the impressive characteristics of Mozart, but he was unusually talented, learningRead MoreThe Music Of Ludwig Van Beethoven1701 Words   |  7 PagesLudwig van Beethoven Music has been around a long time and is a big part of America’s history. There are many styles of music such as, Rap, RB, Jazz, Classical, Oldies and so on. There has been many great composers throughout the years, these people are legends that will stand for ever such as, Beethoven, George Frideric Handel, and Wolfgang Amadeus Mozart. The one artist that I’m going to write about in this paper is the one and only Ludwig van Beethoven. Beethoven was a deaf German composer and theRead MoreJoseph Haydn ( 1732-1809 ) And Ludwig Van Beethoven915 Words   |  4 Pages Both Joseph Haydn (1732-1809) and Ludwig Van Beethoven (1770-1827) as composers, had elements of their environment, personalities and emotions that served as creative inspiration in their music. Both composers’ contributions had profound effects on Western music. According to Greenberg (2009), music composers are basically just people â€Å"who generally prefer their own company to that of others and work best when left alone; they have typically a rather intense personality, not necessarily an antisocialRead MoreMonteverdi, Vivaldi, Pachelbel, And Handel1708 Words   |  7 Pagesmusic. These periods are Baroque, Classical, and Romantic. In these periods there were several different composers who helped shape that period. Here are but a few in each of the period. In the Baroque period, some composers are Vivaldi, Monteverdi, Pachelbel, and Handel. There, of course, are much more as these are just four composers. First, Vivaldi, his full name is Antonio Lucio Vivaldi. Vivaldi was born in 1678 and grew to be an Italian violinist and a composer. He was born with angina pectorisRead MoreCharacteristics Of The Classical Era Of Music729 Words   |  3 Pages Ludwig Van Beethoven was recognized as a great composer in western music. Beethoven was also known for creating the bridge between the classical and romantic era of music. He is known for doing this because he took key aspects of the classical era and merged them with key aspects of the romantic era. The classical era of music dates from 1775-1825. The classical music era had a lighter and more clear texture (Kamien 161). The music from this era was mainly homophonic meaning that the music had

Relationship Between Line Manager Behavior

Question: Discuss about the Relationship Between Line Manager Behavior. Answer: Introduction Employee relation is a crucial aspect of handling of human resources by organizations(Shaw, 2009). Organizations make use of proper employee motivational tools, appropriate leader and job design to increase productivity and commitment from their employees. All these factors jointly in turn affect employee satisfaction levels. The scope of the current case analysis deals with the effects of handling employee relations ineffectively which results in employee dissatisfaction and low levels of commitment. The current case Company has been often accused of handling employees which constitutes its truck drivers in an inappropriate ways and means which resulted in its union leader bargaining with the organization(Alfes, 2013). Later the Company got taken over by a national level Company where employees are greatly valued. Thus, various aspects of employee relation are analyzed in the report. Workplace Practices by new yard manager Work practices at Top Trucking Company at Wollongong yard were traditional in nature being functional as a family business. The family along with the employed manager had a reluctant attitude of negligence towards the truck drivers along with their union leader(Wright, 2007). Whereas in the new national transportation Company which taken over the business of the transportation company had a different attitude towards the drivers. The new Company along with its manager implemented new work practices within the Company that was complementary to the previous prevailing work practices. The new yard manager paid attention to needs and motivational levels of employees. The new Company had a contemporary approach in dealing with the employees by maintaining proper communication with them(Rasulzada, 2009). They had a technique of handling employee grievances and in dealing with any new changes that had to be accommodated with the organization. George, the newly employed yard manager was determined in transforming employee perception regarding the Company. With his determination he was capable of motivating employees and gaining an edge over the previous manager. While the previous manager had a negative influence on the employees, the current manager had a positive role to play. The new Company as a part of employee engagement process renovated and purchased new trucks and also provided drivers dresses, which can be worn during working hours. This led to employee feeling associated with the Company, lifting their morale and motivational levels(Crespo, 2011). The new yard manager along with his existing role of employee engagement was an active leader who worked towards establishing of proper employee relation. His motives were to involve more employees and union leader in order to get productivity to accomplish goals for the organization. This allowed him to establish a greater dependence on employees who were satisfied wi th their roles and current levels of responsibility. The manager often communicated regarding various work targets and pressures by discussing with drivers, which was not attempted earlier. The earlier manager used to treat the employees as not being a part of the Company whereas the new manager made the employees a part of the Company. There is a huge gap in the treatment received from the earlier manager and new manager. The union leader was often referred to for providing suggestions for employee job design and satisfaction. This attitude not only allowed the manager to revive the business but also adopt a suitable organization culture along with work environment. The new Company was greatly involved in establishing a positive employee employer relation that could lead to high levels in employee performance(Kuvaas, 2008). Dependence of new employee relation on leader The truck Company was previously functional and operated in a totally unprofessional manner which led to decrease in productivity levels of employees(Runar Edvardsson, 2008). With the new Company taking over and placing a new leader or manager to handle operations at the truck Company there has been a drastic change undertaken. The role of the new manager had been that of an influential leader who has been able to bring about various changes especially in the field of employee relations. He has established a communication of the employees that constitute the most important resource along with developing relation. He has been greatly instrumental in changing and uplifting of employee morale from being negative towards the Company to being highly positive in nature(Amos, 2008). The new manager deployed by the Company has played the role of transformational leader by incorporating in changes that was previously missing. Especially he has been effective in developing employee level commitment and reducing employee burnout from the current job scenario. His attitude has greatly helped the Company cope with pressures of employee turnover, dissatisfaction and low employee morale(Van De Voorde, 2012). Hence, it has been analyzed that the new visionary leader has been effective in bringing about a new plethora of changes that was otherwise unexpected in the current organization culture. Every transformation within organization takes places through an effective leader who is capable of guiding the process of change. The leader handholds and focuses on employees by convincing them of the changes by making them followers of his. Only a capable leader is able to convince employees into following his footsteps and gaining confidence in him(Renee Baptiste, 2008). There is immense mental dependence that is created by such leaders in him which can be greater than the organization itself. A leader is able to mold his followers and able to maintain effective relations with them. In the current situation the newly employed manager have been able to handle the transition by convincing union leader along with employees to follow him. His charismatic styles and personality have provided impetus for employee productivity enhancement. Through continuing struggle and adaptation of such styles he has been able to change the mental set up of employees towards the organization making t hem focus on goals and objectives(Naseem, 2011). Hence, in case he is changed the employees will eventually lose trust and relation with the organization all over again. This can lead to employees looking for new leader elsewhere, lowering their commitment towards the current organization. It is the first time in the truck company post employing George, the yard manager that a steady employee relation has been developed. It is due to his tremendous leadership qualities that his employees as well as union leader have followed and liked him. His efforts have empowered employees and eventually they have supported him with respect to all decisions undertaken. His followers seek direction from him and feel highly motivated to work along with him(Purcell, 2007). Due to his effort the organization has high levels of employee performance which has in turn enhanced the organizations overall performance. Thus, it becomes imperative to maintain and keep George the newly employed yard manager as the organizational culture promoted by him has been highly effective to increase employee productivity and motivation. Reasons for not accepting changes in Transport Workers Union While globalization and competition amongst industries have led to a number of changes being adopted across organizations, it is always not possible to accommodate changes. Changes within organizations can only be brought about in case the human resource or employees within the organization with help from change management leader are willing to bring about changes. While incorporating in changes might be deemed necessary, various employees and their respective unions are opposed to the entire ideas of change(Innocenti, 2011). Stringent blue collar unions as Transport Workers Union are less likely to agree to changes been adopted within their organizations. These types of blue collar employee union play pertinent roles within employees of an organization and the organization itself, hence there are several fears they attach with the process of change. Influential blue collar employee unions have high roles which they apply in organizations as bargaining employee wages, leaves and other aspects of an employee working within an organization. Organization while adopting change might make roles of these popular employee unions redundant. Organizations employ transformational leader, who is capable of bringing about change. A transformational leader generally applies employee relation and management technique directly with employees(Mowday, 2013). He also establishes communication within the employees which helps establish an organizational culture and employee relation with the Company. With adaptation of changes and improvised workplace related practices roles of employee unions might be viewed as unnecessary. Hence, they often oppose to the process of adopting a change or any practice that can lead to direct communication between the employer and employee. Every organization wants to adopt changes while unions are opposed to them as they are particularly unsure of the effects which such changes might have on the union itself. The goal of every trade union is to establish a relation between the employer and employee through them and not directly, they fear effective changes might dampen such prospects altogether. An effective and capable transformational leader will be capable of bringing about changes by convincing union leader along with employees and create changes for the overall organization. Conclusion Employee relation handling has become the key to establish a higher productivity amongst employer and employee. Such employee relation in turn enable the organization to accomplish productivity and related output levels. The scope of the current case Company provides relevant examples to highlight and depict effectiveness of employee relations. An organization can adopt varied types of strategies such that it is able to attain employee relation management by deploying an effective leader. An organization can also have specific job design for each of its employees and a specific plan for motivation. An attractive job design is a tool often used by corporations to motivate and engage their employees productively. The new manager had been influential in implementing a varied type of strategies that uplifted and provided motivation for the employees. An employee is more likely to deliver high performance and exhibit high satisfaction levels in case he is more engaged with the organizatio n. These effective human resource strategies can help greatly to attain work objectives of organization and help establish a proper employee relation. High employee turnover, employee dissatisfaction and low levels of commitment can greatly reduce employee performance within organization. An organization with dissatisfied employees incurs high costs due to turnover and low levels of commitment. An effective leader can help build bond between the organization and its employees such that employees develop a feeling towards the organization. Thus, it becomes imperative for organizations to deploy suitable strategies for employee engagement and employee motivation. Reference Lists Alfes, K. T. (2013). The relationship between line manager behavior, perceived HRM practices, and individual performance: Examining the mediating role of engagement. . Human resource management, 839-859. Amos, E. A. (2008). An analysis of the relation between employeeOrganization value congruence and employee attitudes. . The journal of psychology, 615-632. Crespo, N. C. (2011). Worksite physical activity policies and environments in relation to employee physical activity. . American Journal of Health Promotion, 264-271. Innocenti, L. P. (2011). Trust as moderator in the relationship between HRM practices and employee attitudes. . Human Resource Management Journal, 303-317. Kuvaas, B. (2008). An exploration of how the employeeorganization relationship affects the linkage between perception of developmental human resource practices and employee outcomes. . Journal of Management Studies, 1-25. Mowday, R. T. (2013). Employeeorganization linkages: The psychology of commitment, absenteeism, and turnover. Academic press. Naseem, A. S. (2011). Impact of employee satisfaction on success of organization: Relation between customer experience and employee satisfaction. International journal of multidisciplinary sciences and engineering, 41-46. Purcell, J. . (2007). HRM and business performance. . Oxford Handbook of Human Resource Management, The, 533. Rasulzada, F. . (2009). Organizational creativity and innovation in relation to psychological well-being and organizational factors. . Creativity Research Journal, 191-198. Renee Baptiste, N. (2008). Tightening the link between employee wellbeing at work and performance: A new dimension for HRM. Management decision, 284-309. Runar Edvardsson, I. (2008). HRM and knowledge management. Employee Relations, 553-561. Shaw, J. D. (2009). Employee-organization exchange relationships, HRM practices, and quit rates of good and poor performers. . Academy of Management Journal, 1016-1033. Van De Voorde, K. P. (2012). Employee well?being and the HRMorganizational performance relationship: a review of quantitative studies. International Journal of Management Reviews, 391-407. Wright, T. A. (2007). The moderating role of employee positive well being on the relation between job satisfaction and job performance. . Journal of occupational health psychology, 93.

Roosevelt, Teddy Essays - , Term Papers, Research Papers

Roosevelt, Teddy He first tried the law profession by enrolling in Columbia University. He did not enjoy it and soon left school. He published his first book in 1882 it was entitled ?The Naval War of 1812?. He had begun work on it while still at Harvard. Then Teddy decided that he would try a career in politics. His first position was on the state assembly in the state of New York. He ran as a republican and won the position easily. At this position he did two major things: first he exposed a corrupt judge and secondly he learned to work with men from both parties. Instead of going for a second term of legislature he decided that he would go to the Republican National Convention in Chicago. He went as the chairman for the New York delegation. While Roosevelt's professional life was flourishing his personal life was not in very good shape. In 1884 both his wife and mother died. His wife died while giving birth to their daughter, Alice. Roosevelt would take a break from politics and form the Elkhorn ranch on the Little Missouri River in the Dakota Territory. On his ranch he led the life of a cowboy. He would round up cattle and ride horses all day. It was a good break for Roosevelt. One story tells of Roosevelt capturing three thieves and holding them at gun point for 6 days until they reached the proper authorities. Also during this time Roosevelt wrote 2 more books (Hunting Trips of a Ranch Man and Thomas Hart Benton) and fell in love with Edith Kermit Carow. On December 2, 1886 Roosevelt and Carow went to London to be married. When they returned to the United States Roosevelt set his mind back on politics. He was very active in the presidential campaign of 1888 when Benjamin Harrison defeated Grover Cleveland. Roosevelt believed in hiring government workers on their skills not based on their party affiliation. At the time the winner of the race would hire every one that had helped them win the race even if they were not qualified for the position. Harrison would award his efforts by appointing him the U.S. Civil Services Commissioner. As commissioner he would continue to challenge ?patronage?. He did such a good job that when Cleveland beat Harrison for reelection he kept him as Civil Services Commissioner. In 1895 Roosevelt would return to New York City to take the position of Police Commissioner. He would battle police corruption and try to reform the police department in his years as commissioner. He would then become Assistant Secretary of the Navy. In 1898 after the U.S. had declared war on Spain Roosevelt resigned from his position so he could form what would become known as the Rough Riders. While in Cuba Teddy would gain fame in the papers for his daring and intelligence in battle. After the war he would be elected governor of New York. Soon afterward New York Senator Thomas Platt would convince him to run with McKinley as Vice President. McKinley won but eight days later he was shot and Roosevelt became President of the United States. AS PRESIDENT One of the major things Roosevelt did as President was come up with what he called the ?Square Deal?. In this ?Square Deal? he planned that everyone would be treated the same and that the rich should not be given special privileges that the poor were not given. One of Roosevelt's more famous quotes was ?Speak softly but carry a big stick?. The big stick was the threat of war on forgein countries. Another major accomplishment of Roosevelt's administration was the building of the Panama Canal which he would supervise during his time in office. In 1904 he would be elected to his second term in office. He defeated Alton B. Parker, a judge who was from New York. During his second term in office he would establish the Pure Food and Drug Act which prevented food that could potential harm you from being sold. He also started major conservation projects to help save forest land and also establish National Parks. In the election of 1908 Roosevelt would not run for the Presidency because he earlier had promised not to run for a third term. This left the Republican slot for president open. It was filled with William Taft who with Roosevelt's backing would wind the presidency. AFTER THE PRESIDENCY Later in 1912 after Taft had enraged him, Roosevelt decided to run for the presidency again. On his campaign tour